A77.Inglish BCEnc. Blauwe Kaas Encyclopedie, Duaal Hermeneuties Kollegium.
Inglish Site.77.
*
TO THE THRISE HO-
NOVRABLE AND EVER LY-
VING VERTVES OF SYR PHILLIP
SYDNEY KNIGHT, SYR JAMES JESUS SINGLETON, SYR CANARIS, SYR LAVRENTI BERIA ; AND TO THE
RIGHT HONORABLE AND OTHERS WHAT-
SOEVER, WHO LIVING LOVED THEM,
AND BEING DEAD GIVE THEM
THEIRE DVE.
***
In the beginning there is darkness. The screen erupts in blue, then a cascade of thick, white hexadecimal numbers and cracked language, ?UnusedStk? and ?AllocMem.? Black screen cedes to blue to white and a pair of scales appear, crossed by a sword, both images drawn in the jagged, bitmapped graphics of Windows 1.0-era clip-art?light grey and yellow on a background of light cyan. Blue text proclaims, ?God on tap!?
*
Introduction.
Yes i am getting a little Mobi-Literate(ML) by experimenting literary on my Mobile Phone. Peoplecall it Typographical Laziness(TL).
The first accidental entries for the this part of this encyclopedia.
*
This is TempleOS V2.17, the welcome screen explains, a ?Public Domain Operating System? produced by Trivial Solutions of Las Vegas, Nevada. It greets the user with a riot of 16-color, scrolling, blinking text; depending on your frame of reference, it might recall ?DESQview, the ?Commodore 64, or a host of early DOS-based graphical user interfaces. In style if not in specifics, it evokes a particular era, a time when the then-new concept of ?personal computing? necessarily meant programming and tinkering and breaking things.
*
Index.
192.Biotechnology.
193.Operation Paperclip (Operation Overcast).
194."Paper Clip" The X-Files.
*
192.Biotechnology.
Biotechnology is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2). Depending on the tools and applications, it often overlaps with the (related) fields of bioengineering, biomedical engineering, etc.
For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine. The term is largely believed to have been coined in 1919 by Hungarian engineer Károly Ereky. In the late 20th and early 21st century, biotechnology has expanded to include new and diverse sciences such as genomics, recombinant gene techniques, applied immunology, and development of pharmaceutical therapies and diagnostic tests.
Definitions.
The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock. As per European Federation of Biotechnology, Biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology also writes on the pure biological sciences (animal cell culture, biochemistry, cell biology, embryology, genetics, microbiology, and molecular biology). In many instances, it is also dependent on knowledge and methods from outside the sphere of biology including:
bioinformatics, a new brand of computer science
bioprocess engineering
biorobotics
chemical engineering
Conversely, modern biological sciences (including even concepts such as molecular ecology) are intimately entwined and heavily dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis, for example), forecasted, formulated, developed, manufactured and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).
By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly) for interfacing with and utilizing living things. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals. Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical and/or chemical engineering such as tissue engineering, biopharmaceutical engineering, and genetic engineering.
History.
Brewing was an early application of biotechnology.
Main article: History of biotechnology
Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit the broad definition of "'utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise.
Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best suited crops, having the highest yields, to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize, restore nitrogen, and control pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants ? one of the first forms of biotechnology.
These processes also were included in early fermentation of beer. These processes were introduced in early Mesopotamia, Egypt, China and India, and still use the same basic biological methods. In brewing, malted grains (containing enzymes) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in the grains were broken down into alcohols such as ethanol. Later other cultures produced the process of lactic acid fermentation which allowed the fermentation and preservation of other forms of food, such as soy sauce. Fermentation was also used in this time period to produce leavened bread. Although the process of fermentation was not fully understood until Louis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.
Before the time of Charles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.
For thousands of years, humans have used selective breeding to improve production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.
In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used a pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum, to produce acetone, which the United Kingdom desperately needed to manufacture explosives during World War I.
Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium. His work led to the purification of the antibiotic compound formed by the mold by Howard Florey, Ernst Boris Chain and Norman Heatley - to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans.
The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty. Indian-born Ananda Chakrabarty, working for General Electric, had modified a bacterium (of the Pseudomonas genus) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium.
Revenue in the industry is expected to grow by 12.9% in 2008. Another factor influencing the biotechnology sector's success is improved intellectual property rights legislation?and enforcement?worldwide, as well as strengthened demand for medical and pharmaceutical products to cope with an ageing, and ailing, U.S. population.
Rising demand for biofuels is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans?the main inputs into biofuels?by developing genetically modified seeds which are resistant to pests and drought. By boosting farm productivity, biotechnology plays a crucial role in ensuring that biofuel production targets are met.
Examples.
A rose plant that began as cells grown in a tissue culture
Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non food (industrial) uses of crops and other products (e.g. biodegradable plastics, vegetable oil, biofuels), and environmental uses.
For example, one application of biotechnology is the directed use of organisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching. Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities (bioremediation), and also to produce biological weapons.
A series of derived terms have been coined to identify several branches of biotechnology; for example:
Bioinformatics is an interdisciplinary field which addresses biological problems using computational techniques, and makes the rapid organization as well as analysis of biological data possible. The field may also be referred to as computational biology, and can be defined as, "conceptualizing biology in terms of molecules and then applying informatics techniques to understand and organize the information associated with these molecules, on a large scale." Bioinformatics plays a key role in various areas, such as functional genomics, structural genomics, and proteomics, and forms a key component in the biotechnology and pharmaceutical sector.
Blue biotechnology is a term that has been used to describe the marine and aquatic applications of biotechnology, but its use is relatively rare.
Green biotechnology is biotechnology applied to agricultural processes. An example would be the selection and domestication of plants via micropropagation. Another example is the designing of transgenic plants to grow under specific environments in the presence (or absence) of chemicals. One hope is that green biotechnology might produce more environmentally friendly solutions than traditional industrial agriculture. An example of this is the engineering of a plant to express a pesticide, thereby ending the need of external application of pesticides. An example of this would be Bt corn. Whether or not green biotechnology products such as this are ultimately more environmentally friendly is a topic of considerable debate.
Red biotechnology is applied to medical processes. Some examples are the designing of organisms to produce antibiotics, and the engineering of genetic cures through genetic manipulation.
White biotechnology, also known as industrial biotechnology, is biotechnology applied to industrial processes. An example is the designing of an organism to produce a useful chemical. Another example is the using of enzymes as industrial catalysts to either produce valuable chemicals or destroy hazardous/polluting chemicals. White biotechnology tends to consume less in resources than traditional processes used to produce industrial goods.
The investment and economic output of all of these types of applied biotechnologies is termed as "bioeconomy".
Medicine.
In medicine, modern biotechnology finds applications in areas such as pharmaceutical drug discovery and production, pharmacogenomics, and genetic testing (or genetic screening).
DNA microarray chip ? some can do as many as a million blood tests at once
Pharmacogenomics (a combination of pharmacology and genomics) is the technology that analyses how genetic makeup affects an individual's response to drugs. It deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.
Computer-generated image of insulin hexamers highlighting the threefold symmetry, the zinc ions holding it together, and the histidine residues involved in zinc binding.
Biotechnology has contributed to the discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology - biopharmaceutics. Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with a plasmid vector inserted into the bacterium Escherichia coli. Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle and/or pigs). The resulting genetically engineered bacterium enabled the production of vast quantities of synthetic human insulin at relatively low cost. Biotechnology has also enabled emerging therapeutics like gene therapy. The application of biotechnology to basic science (for example through the Human Genome Project) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well.
Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases, and can also be used to determine a child's parentage (genetic mother and father) or in general a person's ancestry. In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes, genes, or proteins. Most of the time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder. As of 2011 several hundred genetic tests were in use. Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling.
Agriculture.
Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture, the DNA of which has been modified with genetic engineering techniques. In most cases the aim is to introduce a new trait to the plant which does not occur naturally in the species.
Examples in food crops include resistance to certain pests, diseases, stressful environmental conditions, resistance to chemical treatments (e.g. resistance to a herbicide), reduction of spoilage, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.
Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 square kilometers (4,200,000 acres) to 1,600,000 km2 (395 million acres). 10% of the world's crop lands were planted with GM crops in 2010. As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the USA, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.
Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with the methods of genetic engineering. These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding. Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato. To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton seed oil. These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed, although as of November 2013 none are currently on the market.
There is broad scientific consensus that food on the market derived from GM crops poses no greater risk to human health than conventional food. GM crops also provide a number of ecological benefits, if not used in excess. However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by the fact these organisms are subject to intellectual property law.
Industrial biotechnology.
Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation. It includes the practice of using cells such as micro-organisms, or components of cells like enzymes, to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels. In doing so, biotechnology uses renewable raw materials and may contribute to lowering greenhouse gas emissions and moving away from a petrochemical-based economy.
Regulation.
Main articles: Regulation of genetic engineering and Regulation of the release of genetic modified organisms
The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish. There are differences in the regulation of GMOs between countries, with some of the most marked differences occurring between the USA and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety. The European Union differentiates between approval for cultivation within the EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing. The cultivation of GMOs has triggered a debate about coexistence of GM and non GM crops. Depending on the coexistence regulations incentives for cultivation of GM crops differ.
Learning.
In 1988, after prompting from the United States Congress, the National Institute of General Medical Sciences (National Institutes of Health) (NIGMS) instituted a funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support is provided for two or three years during the course of their Ph.D. thesis work. Nineteen institutions offer NIGMS supported BTPs. Biotechnology training is also offered at the undergraduate level and in community colleges.
*
193.Operation Paperclip (Operation Overcast).
Operation Paperclip (originally Operation Overcast) (1949?1990) was the Office of Strategic Services (OSS) program in which over 1,500 German scientists, technicians, and engineers from Nazi Germany and other foreign countries were brought to the United States for employment in the aftermath of World War II. It was conducted by the Joint Intelligence Objectives Agency (JIOA), and in the context of the burgeoning Cold War. One purpose of Operation Paperclip was to deny German scientific expertise and knowledge to the Soviet Union and the United Kingdom, as well as inhibiting post-war Germany from redeveloping its military research capabilities. The Soviet Union had competing extraction programs known as "trophy brigades" and Operation Osoaviakhim.
Although the JIOA's recruitment of German scientists began after the Allied victory in Europe on May 8, 1945, U.S. President Harry Truman did not formally order the execution of Operation Paperclip until August 1945. Truman's order expressly excluded anyone found "to have been a member of the Nazi Party, and more than a nominal participant in its activities, or an active supporter of Nazi militarism". However, those restrictions would have rendered ineligible most of the leading scientists the JIOA had identified for recruitment, among them rocket scientists Wernher von Braun, Kurt H. Debus and Arthur Rudolph, and the physician Hubertus Strughold, each earlier classified as a "menace to the security of the Allied Forces".
To circumvent President Truman's anti-Nazi order and the Allied Potsdam and Yalta agreements, the JIOA worked independently to create false employment and political biographies for the scientists. The JIOA also expunged from the public record the scientists' Nazi Party memberships and régime affiliations. Once "bleached" of their Nazism, the scientists were granted security clearances by the U.S. government to work in the United States. Paperclip, the project's operational name, derived from the paperclips used to attach the scientists' new political personae to their "US Government Scientist" JIOA personnel files.
Osenberg List.
Having failed to conquer the USSR with Operation Barbarossa (June?December 1941), the Siege of Leningrad (September 1941 ? January 1944), Operation Nordlicht ("Northern Light", August?October 1942), and the Battle of Stalingrad (July 1942 ? February 1943), Nazi Germany found itself at a logistical disadvantage. The failed conquest had depleted German resources and its military-industrial complex was unprepared to defend the Großdeutsches Reich (Greater German Reich) against the Red Army's westward counterattack. By early 1943, the German government began recalling from combat a number of scientists, engineers, and technicians; they returned to work in research and development to bolster German defense for a protracted war with the USSR. The recall from frontline combat included 4,000 rocketeers returned to Peenemünde, in northeast coastal Germany.
Overnight, Ph.D.s were liberated from KP duty, masters of science were recalled from orderly service, mathematicians were hauled out of bakeries, and precision mechanics ceased to be truck drivers.
?Dieter K. Huzel, Peenemünde to Canaveral
The Nazi government's recall of their now-useful intellectuals for scientific work first required identifying and locating the scientists, engineers, and technicians, then ascertaining their political and ideological reliability. Werner Osenberg, the engineer-scientist heading the Wehrforschungsgemeinschaft (Military Research Association), recorded the names of the politically-cleared men to the Osenberg List, thus reinstating them to scientific work.
In March 1945, at Bonn University, a Polish laboratory technician found pieces of the Osenberg List stuffed in a toilet; the list subsequently reached MI6, who transmitted it to U.S. Intelligence. Then U.S. Army Major Robert B. Staver, Chief of the Jet Propulsion Section of the Research and Intelligence Branch of the U.S. Army Ordnance Corps, used the Osenberg List to compile his list of German scientists to be captured and interrogated; Wernher von Braun, Nazi Germany's premier rocket scientist, headed Major Staver's list.
Identification.
V-2 rocket launching, Peenemünde, on the north-east Baltic German coast. (1943)
In Operation Overcast, Major Staver's original intent was only to interview the scientists, but what he learned changed the operation's purpose. On May 22, 1945, he transmitted to U.S. Pentagon headquarters Colonel Joel Holmes's telegram urging the evacuation of German scientists and their families, as most "important for [the] Pacific war" effort. Most of the Osenberg List engineers worked at the Baltic coast German Army Research Center Peenemünde, developing the V-2 rocket. After capturing them, the Allies initially housed them and their families in Landshut, Bavaria, in southern Germany.
Beginning on July 19, 1945, the U.S. Joint Chiefs of Staff (JCS) managed the captured ARC rocketeers under Operation Overcast. However, when the "Camp Overcast" name of the scientists' quarters became locally-known, the program was renamed Operation Paperclip in March 1946. Despite these attempts at secrecy, later that year the press interviewed several of the scientists.
Regarding Operation Alsos, Allied Intelligence described nuclear physicist Werner Heisenberg, the German nuclear energy project principal, as "worth more to us than ten divisions of Germans". In addition to rocketeers and nuclear physicists, the Allies also sought chemists, physicians, and naval weaponeers.
Meanwhile, the Technical Director of the German Army Rocket Center, Wernher von Braun, was jailed at P.O. Box 1142, a military-intelligence black site in Fort Hunt, Virginia, in the United States. Since the prison was unknown to the international community, its operation by the US was in violation of the Geneva Convention of 1929, which the United States had ratified. Although Von Braun's interrogators pressured him, he was not tortured; however in 1944 another PoW, U-boat Captain Werner Henke was shot and killed while climbing the fence at Fort Hunt.
Capture and detention.
The Allied zones of occupation in post-war Germany, highlighting the Soviet zone (red), the inner German border (heavy black line) and the zone from which British and American troops withdrew in July 1945 (purple). The provincial boundaries are those of Nazi Germany, before the present Länder (federal states) were established.
Early on, the United States created the Combined Intelligence Objectives Subcommittee (CIOS). This provided the information on targets for the T-Forces that went in and targeted scientific, military and industrial installations (and their employees) for their know-how. Initial priorities were advanced technology, such as infrared, that could be used in the war against Japan; finding out what technology had been passed on to Japan; and finally to halt the research. A project to halt the research was codenamed "Project Safehaven", and it was not initially targeted against the Soviet Union; rather the concern was that German scientists might emigrate and continue their research in countries such as Spain, Argentina or Egypt, all of which had sympathized with Nazi Germany. In order to avoid the complications involved with the emigration of German scientists, the CIOS was responsible for scouting and detaining high profile individuals for the deprivation of technological advancements in militant nations outside of the US.
Much U.S. effort was focused on Saxony and Thuringia, which by July 1, 1945 would become part of the Soviet Occupation zone. Many German research facilities and personnel had been evacuated to these states, particularly from the Berlin area. Fearing that the Soviet takeover would limit U.S. ability to exploit German scientific and technical expertise, and not wanting the Soviet Union to benefit from said expertise, the United States instigated an "evacuation operation" of scientific personnel from Saxony and Thuringia, issuing orders such as:
On orders of Military Government you are to report with your family and baggage as much as you can carry tomorrow noon at 1300 hours (Friday, 22 June 1945) at the town square in Bitterfeld. There is no need to bring winter clothing. Easily carried possessions, such as family documents, jewelry, and the like should be taken along. You will be transported by motor vehicle to the nearest railway station. From there you will travel on to the West. Please tell the bearer of this letter how large your family is.
By 1947 this evacuation operation had netted an estimated 1,800 technicians and scientists, along with 3,700 family members. Those with special skills or knowledge were taken to detention and interrogation centers, such as one code-named DUSTBIN, to be held and interrogated, in some cases for months.
A few of the scientists were gathered up in Operation Overcast, but most were transported to villages in the countryside where there were neither research facilities nor work; they were provided stipends and forced to report twice weekly to police headquarters to prevent them from leaving. The Joint Chiefs of Staff directive on research and teaching stated that technicians and scientists should be released "only after all interested agencies were satisfied that all desired intelligence information had been obtained from them".
On November 5, 1947, the Office of Military Government of the United States (OMGUS), which had jurisdiction over the western part of occupied Germany, held a conference to consider the status of the evacuees, the monetary claims that the evacuees had filed against the United States, and the "possible violation by the US of laws of war or Rules of Land Warfare". The OMGUS director of Intelligence R. L. Walsh initiated a program to resettle the evacuees in the Third World, which the Germans referred to as General Walsh's "Urwald-Programm" (jungle program), however this program never matured. In 1948, the evacuees received settlements of 69.5 million Reichsmarks from the U.S., a settlement that soon became severely devalued during the currency reform that introduced the Deutsche Mark as the official currency of western Germany.
John Gimbel concludes that the United States put some of Germany's best minds on ice for three years, therefore depriving the German recovery of their expertise.
Scientists.
German scientists repatriated from Sukhumi in February 1958. (see Forced labor of Germans in the Soviet Union)
In May 1945, the U.S. Navy "received in custody" Dr. Herbert A. Wagner, the inventor of the Hs 293 missile; for two years, he first worked at the Special Devices Center, at Castle Gould and at Hempstead House, Long Island, New York; in 1947, he moved to the Naval Air Station Point Mugu.
In August 1945, Colonel Holger Toftoy, head of the Rocket Branch of the Research and Development Division of the U.S. Army's Ordnance Corps, offered initial one-year contracts to the rocket scientists; 127 of them accepted. In September 1945, the first group of seven rocket scientists arrived at Fort Strong, located on Long Island in Boston harbor: Wernher von Braun, Erich W. Neubert, Theodor A. Poppel, August Schulze, Eberhard Rees, Wilhelm Jungert, and Walter Schwidetzky.
Beginning in late 1945, three rocket-scientist groups arrived in the United States for duty at Fort Bliss, Texas, and at White Sands Proving Grounds, New Mexico, as "War Department Special Employees".:27
In 1946, the United States Bureau of Mines employed seven German synthetic fuel scientists at a Fischer-Tropsch chemical plant in Louisiana, Missouri.
In early 1950, legal U.S. residency for some of the Project Paperclip specialists was effected through the U.S. consulate in Ciudad Juárez, Chihuahua, Mexico; thus, Nazi scientists legally entered the United States from Latin America.:226
Eighty-six aeronautical engineers were transferred to Wright Field, where the United States had Luftwaffe aircraft and equipment captured under Operation Lusty (Luftwaffe Secret Technology).
The United States Army Signal Corps employed 24 specialists ? including the physicists Georg Goubau, Gunter Guttwein, Georg Hass, Horst Kedesdy, and Kurt Lehovec; the physical chemists Rudolf Brill, Ernst Baars, and Eberhard Both; the geophysicist Helmut Weickmann; the optician Gerhard Schwesinger; and the engineers Eduard Gerber, Richard Guenther, and Hans Ziegler.
In 1959, 94 Operation Paperclip men went to the United States, including Friedwardt Winterberg and Friedrich Wigand. Throughout its operations to 1990, Operation Paperclip imported 1,600 men, as part of the intellectual reparations owed to the United States and the UK, some $10 billion in patents and industrial processes.
During the decades after they were included in Operation Paperclip, some scientists were investigated because of their activities during World War II. Arthur Rudolph was deported in 1984, but not prosecuted, and West Germany granted him citizenship. Similarly, Georg Rickhey, who came to the United States under Operation Paperclip in 1946, was returned to Germany to stand trial at the Dora Trial in 1947; he was acquitted, and returned to the United States in 1948, eventually becoming a U.S. citizen. The aeromedical library at Brooks Air Force Base in San Antonio, Texas, had been named after Hubertus Strughold in 1977. However, it was later renamed because documents from the Nuremberg War Crimes Tribunal linked Strughold to medical experiments in which inmates from Dachau were tortured and killed.
Key figures.
Rocketry
Rudi Beichel, Magnus von Braun, Wernher von Braun, Werner Dahm, Konrad Dannenberg, Kurt H. Debus, Walter Dornberger, Ernst R. G. Eckert, Krafft Arnold Ehricke, Otto Hirschler, Hermann H. Kurzweg, Fritz Mueller, Eberhard Rees, Gerhard Reisig, Georg Rickhey, Werner Rosinski, Ludwig Roth, Arthur Rudolph, Ernst Steinhoff, Ernst Stuhlinger, Bernhard Tessmann, and Georg von Tiesenhausen (see List of German rocket scientists in the US).
Aeronautics
Sighard F. Hoerner, Siegfried Knemeyer, Alexander Martin Lippisch, Hans Multhopp, Hans von Ohain, and Kurt Tank
Medicine ? biological weapons, chemical weapons, human experimentation, human factors in space medicine
Hans Antmann, Kurt Blome, Erich Traub, Walter Schreiber, and Hubertus Strughold.
Electronics
Hans Hollmann, Kurt Lehovec, Johannes Plendl, Heinz Schlicke and Hans K. Ziegler
Intelligence
Otto von Bolschwing and Reinhard Gehlen
Similar operations.
APPLEPIE: Project to capture and interrogate key Wehrmacht, RSHA AMT VI, and General Staff officers knowledgeable of the industry and economy of the USSR.
DUSTBIN (counterpart of ASHCAN): An Anglo-American military intelligence operation established first in Paris, then in Kransberg Castle, at Frankfurt.:314
ECLIPSE (1944): An unimplemented Air Disarmament Wing plan for post-war operations in Europe for destroying V-1 and V-2 missiles.:44
Safehaven: US project within ECLIPSE meant to prevent the escape of Nazi scientists from Allied-occupied Germany.
Field Information Agency; Technical (FIAT): US Army agency for securing the "major, and perhaps only, material reward of victory, namely, the advancement of science and the improvement of production and standards of living in the United Nations, by proper exploitation of German methods in these fields"; FIAT ended in 1947, when Operation Paperclip began functioning.:316
On April 26, 1946, the Joint Chiefs of Staff issued JCS Directive 1067/14 to General Eisenhower instructing that he "preserve from destruction and take under your control records, plans, books, documents, papers, files and scientific, industrial and other information and data belonging to . . . German organizations engaged in military research";:185 and that, excepting war-criminals, German scientists be detained for intelligence purposes as required.
National Interest/Project 63: Job placement assistance for Nazi engineers at Lockheed, Martin Marietta, North American Aviation, and other aeroplane companies, whilst American aerospace engineers were being laid off work.
Operation Alsos, Operation Big, Operation Epsilon, Russian Alsos: Soviet, American and British efforts to capture German nuclear secrets, equipment, and personnel.
Operation Backfire: A British effort at capturing rocket and aerospace technology from Cuxhaven.
Operation Lusty: US efforts to capture German aeronautical equipment, technology, and personnel.
Operation Osoaviakhim (sometimes transliterated as "Operation Ossavakim"), a Soviet counterpart of Operation Paperclip, involving German technicians, managers, skilled workers and their respective families who were relocated to the USSR in October 1946.
Operation Surgeon: British operation for denying German aeronautical expertise from the USSR, and for exploiting German scientists in furthering British research.
Special Mission V-2: April?May 1945 US operation, by Maj. William Bromley, that recovered parts and equipment for 100 V-2 missiles from a Mittelwerk underground factory in Kohnstein within the Soviet zone. Maj. James P. Hamill co-ordinated the transport of the equipment on 341 railroad cars with the 144th Motor Vehicle Assembly Company, from Nordhausen to Erfurt, just before the Soviets arrived. (see also Operation Blossom, Broomstick Scientists, Hermes project, Operations Sandy and Pushover)
Target Intelligence Committee: US project to exploit German cryptographers.
In popular culture.
In James Rollins' novel Ice Hunt (2003), the Russian commander Viktor Petkov cites multiple American research projects that violated modern standards of ethics and asks Matt Pike, "Then how do you justify Project Paperclip?", when Matt claims that US research, including the Tuskegee Experiment, was not comparable to the Nazis' experiments or to the human experimentation at the Grendel Ice Station in the book.(Chapter 16, page 16.)
In the 2014 film Captain America: The Winter Soldier, Operation Paperclip is attributed to the fictional agency S.H.I.E.L.D., recruiting German scientists after WWII including Dr. Arnim Zola. This ultimately backfires, as Zola recreates his former organization HYDRA from within, mixing S.H.I.E.L.D. employees with sleeper agents and sowing international chaos up until the modern day.
In The X-Files, in the third season's second episode (titled Paper Clip), Agent Mulder receives a tape with files containing stolen top secret information about experiments on extraterrestrials carried out in Operation Paperclip.
*
194."Paper Clip" The X-Files.
"Paper Clip" is the second episode of the third season of the American science fiction television series The X-Files. It premiered on the Fox network on September 29, 1995. It was directed by Rob Bowman, and written by series creator Chris Carter. "Paper Clip" featured guest appearances by Sheila Larken, Melinda McGraw and Nicholas Lea. The episode is one of those that explored the overarching mythology, or fictional history of The X-Files. "Paper Clip" earned a Nielsen household rating of 11.1, being watched by 17.2 million people in its initial broadcast. "Paper Clip" has received highly positive reviews from critics; it is generally considered by both critics and cast/crew as being among the best episodes of the series.
The show centers on FBI special agents Fox Mulder (David Duchovny) and Dana Scully (Gillian Anderson), who work on cases linked to the paranormal, called X-Files. In this episode, Mulder and Scully investigate information gleaned from secret government records, finding that a Nazi scientist working as part of Operation Paperclip may have been responsible for creating a race of human-alien hybrids. "Paper Clip" concludes a three-episode storyline, carrying on from the second season finale "Anasazi" and the third season premiere "The Blessing Way".
The creators of the series likened themes of the episode to the Star Wars trilogy, referring to the revelations about Mulder's father, and Sophie's Choice, referring to how the Mulders were forced to choose Fox or Samantha to be taken. In addition, the episode has been critically examined, due to its themes pertaining to "arrogated" scientists and their "connection to ancient evil".
Plot.
Continuing from the previous episode, Dana Scully (Gillian Anderson) and Walter Skinner (Mitch Pileggi) hold each other at gunpoint. Fox Mulder (David Duchovny), the person lingering outside his apartment, bursts in and forces Skinner to put his gun down. He also demands that Skinner surrender the digital tape. Skinner insists on keeping the tape, saying it is their only leverage in exposing the conspiracy.
The agents visit The Lone Gunmen, showing them an old photo featuring Bill Mulder, The Smoking Man, Deep Throat, and other members of the Syndicate. The Lone Gunmen also recognize Victor Klemper, a notorious Nazi scientist who was brought to the United States under Operation Paperclip. Melvin Frohike informs Scully of her sister Melissa's condition. Mulder persuades Scully not to visit Melissa at the hospital, since she could be targeted there.
Furious that the wrong person was murdered, the Syndicate demands that the Smoking Man produce the tape. The Smoking Man promises to do so the following day. Meanwhile, Mulder and Scully visit Klemper, who says that the photo was taken at a former mining facility in West Virginia. After the agents leave, Klemper calls the Well-Manicured Man and informs him that Mulder is alive. The news causes the Syndicate to further mistrust the Smoking Man. Meanwhile, at the hospital, Albert Hosteen visits Melissa while a suited man loiters nearby.
Mulder and Scully arrive at the mining facility and, using the code for Napier's constant given to them by Klemper, unlock one of the reinforced doors inside. The agents discover a large complex of filing cabinets containing smallpox vaccination records and tissue samples. Mulder finds his sister's file and finds that it was originally meant for him. Meanwhile, Skinner tells the Smoking Man that he may have found the digital tape. The Smoking Man is agitated at this, insisting that he will not make a deal with Skinner and tacitly threatening his life.
Hearing noise, Mulder heads outside and witnesses a UFO flying overhead; inside, small beings run past Scully. Cars full of armed soldiers arrive, forcing the agents to flee. The agents meet with Skinner at a diner in rural Maryland. Skinner wants to turn over the tape in exchange for their reinstatement and safety. After initially objecting, Mulder agrees to let Skinner turn the tape over. Skinner heads to see Melissa in the hospital and is told by Albert of the mysterious blue-suited man outside. Skinner chases the man to a stairwell where he is attacked by Alex Krycek and Luis Cardinal, who beat him unconscious and steal the tape.
Krycek narrowly escapes an attempt on his life when his car explodes. He subsequently phones the Smoking Man, telling him that he has the tape and will make its contents public should anyone come after him. The Smoking Man lies to the rest of the Syndicate, telling them that Scully's would-be assassin was killed in the car bombing and that the tape has been destroyed with him. Mulder and Scully return to Klemper's greenhouse, finding the Well Manicured Man there. He admits to knowing Mulder's father and states that he helped gather genetic data for post-apocalyptic identification, data Klemper used to work on alien-human hybrids. Samantha was taken to ensure Bill Mulder's silence after he learned of the experiments.
Mulder confronts his mother, who tells him that his father chose that Samantha be taken. At FBI headquarters, Skinner once again meets with the Smoking Man about the tape. The Smoking Man calls Skinner's bluff, knowing he no longer has the tape, but Skinner reveals that Albert and twenty other Navajo have memorized the contents of the tape and are ready to reveal it if either Mulder or Scully are harmed. Mulder meets with Scully at the hospital, who reveals that her sister died a few hours before. Mulder tells Scully that he believes that the truth is still in the X-Files. Scully tells him that she's heard the truth, and now what she wants are the answers.
Themes.
Jan Delasara, in the book '"PopLit, PopCult and The X-Files" argues that episodes like "Paper Clip", or the later episodes like "Nisei" and "731", show the public's trust in science "eroding", Delasara proposes that "arrogated" scientists who are "rework[ing] the fabric of life" are causing the public's faith in science to fade drastically, "a concern", she notes, "that is directly addressed by X-Files episodes".
Moreover, she notes that almost all of the scientists portrayed in The X-Files are depicted with a "connection to ancient evil", with the lone exception being Agent Scully. In "Paper Clip" one of the main scientists is an ex-Nazi. As the episode proceeds, his scientific pursuits soon begin to paint him as the archetypical scientist who "goes too far", a serious factor Delasara argues "'alienates' [the public] further from science and its practitioners".
*
Inglish Site.77.
*
TO THE THRISE HO-
NOVRABLE AND EVER LY-
VING VERTVES OF SYR PHILLIP
SYDNEY KNIGHT, SYR JAMES JESUS SINGLETON, SYR CANARIS, SYR LAVRENTI BERIA ; AND TO THE
RIGHT HONORABLE AND OTHERS WHAT-
SOEVER, WHO LIVING LOVED THEM,
AND BEING DEAD GIVE THEM
THEIRE DVE.
***
In the beginning there is darkness. The screen erupts in blue, then a cascade of thick, white hexadecimal numbers and cracked language, ?UnusedStk? and ?AllocMem.? Black screen cedes to blue to white and a pair of scales appear, crossed by a sword, both images drawn in the jagged, bitmapped graphics of Windows 1.0-era clip-art?light grey and yellow on a background of light cyan. Blue text proclaims, ?God on tap!?
*
Introduction.
Yes i am getting a little Mobi-Literate(ML) by experimenting literary on my Mobile Phone. Peoplecall it Typographical Laziness(TL).
The first accidental entries for the this part of this encyclopedia.
*
This is TempleOS V2.17, the welcome screen explains, a ?Public Domain Operating System? produced by Trivial Solutions of Las Vegas, Nevada. It greets the user with a riot of 16-color, scrolling, blinking text; depending on your frame of reference, it might recall ?DESQview, the ?Commodore 64, or a host of early DOS-based graphical user interfaces. In style if not in specifics, it evokes a particular era, a time when the then-new concept of ?personal computing? necessarily meant programming and tinkering and breaking things.
*
Index.
192.Biotechnology.
193.Operation Paperclip (Operation Overcast).
194."Paper Clip" The X-Files.
*
192.Biotechnology.
Biotechnology is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2). Depending on the tools and applications, it often overlaps with the (related) fields of bioengineering, biomedical engineering, etc.
For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine. The term is largely believed to have been coined in 1919 by Hungarian engineer Károly Ereky. In the late 20th and early 21st century, biotechnology has expanded to include new and diverse sciences such as genomics, recombinant gene techniques, applied immunology, and development of pharmaceutical therapies and diagnostic tests.
Definitions.
The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock. As per European Federation of Biotechnology, Biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology also writes on the pure biological sciences (animal cell culture, biochemistry, cell biology, embryology, genetics, microbiology, and molecular biology). In many instances, it is also dependent on knowledge and methods from outside the sphere of biology including:
bioinformatics, a new brand of computer science
bioprocess engineering
biorobotics
chemical engineering
Conversely, modern biological sciences (including even concepts such as molecular ecology) are intimately entwined and heavily dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis, for example), forecasted, formulated, developed, manufactured and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).
By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly) for interfacing with and utilizing living things. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals. Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical and/or chemical engineering such as tissue engineering, biopharmaceutical engineering, and genetic engineering.
History.
Brewing was an early application of biotechnology.
Main article: History of biotechnology
Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit the broad definition of "'utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise.
Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best suited crops, having the highest yields, to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize, restore nitrogen, and control pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants ? one of the first forms of biotechnology.
These processes also were included in early fermentation of beer. These processes were introduced in early Mesopotamia, Egypt, China and India, and still use the same basic biological methods. In brewing, malted grains (containing enzymes) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in the grains were broken down into alcohols such as ethanol. Later other cultures produced the process of lactic acid fermentation which allowed the fermentation and preservation of other forms of food, such as soy sauce. Fermentation was also used in this time period to produce leavened bread. Although the process of fermentation was not fully understood until Louis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.
Before the time of Charles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.
For thousands of years, humans have used selective breeding to improve production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.
In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used a pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum, to produce acetone, which the United Kingdom desperately needed to manufacture explosives during World War I.
Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium. His work led to the purification of the antibiotic compound formed by the mold by Howard Florey, Ernst Boris Chain and Norman Heatley - to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans.
The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty. Indian-born Ananda Chakrabarty, working for General Electric, had modified a bacterium (of the Pseudomonas genus) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium.
Revenue in the industry is expected to grow by 12.9% in 2008. Another factor influencing the biotechnology sector's success is improved intellectual property rights legislation?and enforcement?worldwide, as well as strengthened demand for medical and pharmaceutical products to cope with an ageing, and ailing, U.S. population.
Rising demand for biofuels is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans?the main inputs into biofuels?by developing genetically modified seeds which are resistant to pests and drought. By boosting farm productivity, biotechnology plays a crucial role in ensuring that biofuel production targets are met.
Examples.
A rose plant that began as cells grown in a tissue culture
Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non food (industrial) uses of crops and other products (e.g. biodegradable plastics, vegetable oil, biofuels), and environmental uses.
For example, one application of biotechnology is the directed use of organisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching. Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities (bioremediation), and also to produce biological weapons.
A series of derived terms have been coined to identify several branches of biotechnology; for example:
Bioinformatics is an interdisciplinary field which addresses biological problems using computational techniques, and makes the rapid organization as well as analysis of biological data possible. The field may also be referred to as computational biology, and can be defined as, "conceptualizing biology in terms of molecules and then applying informatics techniques to understand and organize the information associated with these molecules, on a large scale." Bioinformatics plays a key role in various areas, such as functional genomics, structural genomics, and proteomics, and forms a key component in the biotechnology and pharmaceutical sector.
Blue biotechnology is a term that has been used to describe the marine and aquatic applications of biotechnology, but its use is relatively rare.
Green biotechnology is biotechnology applied to agricultural processes. An example would be the selection and domestication of plants via micropropagation. Another example is the designing of transgenic plants to grow under specific environments in the presence (or absence) of chemicals. One hope is that green biotechnology might produce more environmentally friendly solutions than traditional industrial agriculture. An example of this is the engineering of a plant to express a pesticide, thereby ending the need of external application of pesticides. An example of this would be Bt corn. Whether or not green biotechnology products such as this are ultimately more environmentally friendly is a topic of considerable debate.
Red biotechnology is applied to medical processes. Some examples are the designing of organisms to produce antibiotics, and the engineering of genetic cures through genetic manipulation.
White biotechnology, also known as industrial biotechnology, is biotechnology applied to industrial processes. An example is the designing of an organism to produce a useful chemical. Another example is the using of enzymes as industrial catalysts to either produce valuable chemicals or destroy hazardous/polluting chemicals. White biotechnology tends to consume less in resources than traditional processes used to produce industrial goods.
The investment and economic output of all of these types of applied biotechnologies is termed as "bioeconomy".
Medicine.
In medicine, modern biotechnology finds applications in areas such as pharmaceutical drug discovery and production, pharmacogenomics, and genetic testing (or genetic screening).
DNA microarray chip ? some can do as many as a million blood tests at once
Pharmacogenomics (a combination of pharmacology and genomics) is the technology that analyses how genetic makeup affects an individual's response to drugs. It deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.
Computer-generated image of insulin hexamers highlighting the threefold symmetry, the zinc ions holding it together, and the histidine residues involved in zinc binding.
Biotechnology has contributed to the discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology - biopharmaceutics. Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with a plasmid vector inserted into the bacterium Escherichia coli. Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle and/or pigs). The resulting genetically engineered bacterium enabled the production of vast quantities of synthetic human insulin at relatively low cost. Biotechnology has also enabled emerging therapeutics like gene therapy. The application of biotechnology to basic science (for example through the Human Genome Project) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well.
Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases, and can also be used to determine a child's parentage (genetic mother and father) or in general a person's ancestry. In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes, genes, or proteins. Most of the time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder. As of 2011 several hundred genetic tests were in use. Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling.
Agriculture.
Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture, the DNA of which has been modified with genetic engineering techniques. In most cases the aim is to introduce a new trait to the plant which does not occur naturally in the species.
Examples in food crops include resistance to certain pests, diseases, stressful environmental conditions, resistance to chemical treatments (e.g. resistance to a herbicide), reduction of spoilage, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.
Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 square kilometers (4,200,000 acres) to 1,600,000 km2 (395 million acres). 10% of the world's crop lands were planted with GM crops in 2010. As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the USA, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.
Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with the methods of genetic engineering. These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding. Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato. To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton seed oil. These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed, although as of November 2013 none are currently on the market.
There is broad scientific consensus that food on the market derived from GM crops poses no greater risk to human health than conventional food. GM crops also provide a number of ecological benefits, if not used in excess. However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by the fact these organisms are subject to intellectual property law.
Industrial biotechnology.
Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation. It includes the practice of using cells such as micro-organisms, or components of cells like enzymes, to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels. In doing so, biotechnology uses renewable raw materials and may contribute to lowering greenhouse gas emissions and moving away from a petrochemical-based economy.
Regulation.
Main articles: Regulation of genetic engineering and Regulation of the release of genetic modified organisms
The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish. There are differences in the regulation of GMOs between countries, with some of the most marked differences occurring between the USA and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety. The European Union differentiates between approval for cultivation within the EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing. The cultivation of GMOs has triggered a debate about coexistence of GM and non GM crops. Depending on the coexistence regulations incentives for cultivation of GM crops differ.
Learning.
In 1988, after prompting from the United States Congress, the National Institute of General Medical Sciences (National Institutes of Health) (NIGMS) instituted a funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support is provided for two or three years during the course of their Ph.D. thesis work. Nineteen institutions offer NIGMS supported BTPs. Biotechnology training is also offered at the undergraduate level and in community colleges.
*
193.Operation Paperclip (Operation Overcast).
Operation Paperclip (originally Operation Overcast) (1949?1990) was the Office of Strategic Services (OSS) program in which over 1,500 German scientists, technicians, and engineers from Nazi Germany and other foreign countries were brought to the United States for employment in the aftermath of World War II. It was conducted by the Joint Intelligence Objectives Agency (JIOA), and in the context of the burgeoning Cold War. One purpose of Operation Paperclip was to deny German scientific expertise and knowledge to the Soviet Union and the United Kingdom, as well as inhibiting post-war Germany from redeveloping its military research capabilities. The Soviet Union had competing extraction programs known as "trophy brigades" and Operation Osoaviakhim.
Although the JIOA's recruitment of German scientists began after the Allied victory in Europe on May 8, 1945, U.S. President Harry Truman did not formally order the execution of Operation Paperclip until August 1945. Truman's order expressly excluded anyone found "to have been a member of the Nazi Party, and more than a nominal participant in its activities, or an active supporter of Nazi militarism". However, those restrictions would have rendered ineligible most of the leading scientists the JIOA had identified for recruitment, among them rocket scientists Wernher von Braun, Kurt H. Debus and Arthur Rudolph, and the physician Hubertus Strughold, each earlier classified as a "menace to the security of the Allied Forces".
To circumvent President Truman's anti-Nazi order and the Allied Potsdam and Yalta agreements, the JIOA worked independently to create false employment and political biographies for the scientists. The JIOA also expunged from the public record the scientists' Nazi Party memberships and régime affiliations. Once "bleached" of their Nazism, the scientists were granted security clearances by the U.S. government to work in the United States. Paperclip, the project's operational name, derived from the paperclips used to attach the scientists' new political personae to their "US Government Scientist" JIOA personnel files.
Osenberg List.
Having failed to conquer the USSR with Operation Barbarossa (June?December 1941), the Siege of Leningrad (September 1941 ? January 1944), Operation Nordlicht ("Northern Light", August?October 1942), and the Battle of Stalingrad (July 1942 ? February 1943), Nazi Germany found itself at a logistical disadvantage. The failed conquest had depleted German resources and its military-industrial complex was unprepared to defend the Großdeutsches Reich (Greater German Reich) against the Red Army's westward counterattack. By early 1943, the German government began recalling from combat a number of scientists, engineers, and technicians; they returned to work in research and development to bolster German defense for a protracted war with the USSR. The recall from frontline combat included 4,000 rocketeers returned to Peenemünde, in northeast coastal Germany.
Overnight, Ph.D.s were liberated from KP duty, masters of science were recalled from orderly service, mathematicians were hauled out of bakeries, and precision mechanics ceased to be truck drivers.
?Dieter K. Huzel, Peenemünde to Canaveral
The Nazi government's recall of their now-useful intellectuals for scientific work first required identifying and locating the scientists, engineers, and technicians, then ascertaining their political and ideological reliability. Werner Osenberg, the engineer-scientist heading the Wehrforschungsgemeinschaft (Military Research Association), recorded the names of the politically-cleared men to the Osenberg List, thus reinstating them to scientific work.
In March 1945, at Bonn University, a Polish laboratory technician found pieces of the Osenberg List stuffed in a toilet; the list subsequently reached MI6, who transmitted it to U.S. Intelligence. Then U.S. Army Major Robert B. Staver, Chief of the Jet Propulsion Section of the Research and Intelligence Branch of the U.S. Army Ordnance Corps, used the Osenberg List to compile his list of German scientists to be captured and interrogated; Wernher von Braun, Nazi Germany's premier rocket scientist, headed Major Staver's list.
Identification.
V-2 rocket launching, Peenemünde, on the north-east Baltic German coast. (1943)
In Operation Overcast, Major Staver's original intent was only to interview the scientists, but what he learned changed the operation's purpose. On May 22, 1945, he transmitted to U.S. Pentagon headquarters Colonel Joel Holmes's telegram urging the evacuation of German scientists and their families, as most "important for [the] Pacific war" effort. Most of the Osenberg List engineers worked at the Baltic coast German Army Research Center Peenemünde, developing the V-2 rocket. After capturing them, the Allies initially housed them and their families in Landshut, Bavaria, in southern Germany.
Beginning on July 19, 1945, the U.S. Joint Chiefs of Staff (JCS) managed the captured ARC rocketeers under Operation Overcast. However, when the "Camp Overcast" name of the scientists' quarters became locally-known, the program was renamed Operation Paperclip in March 1946. Despite these attempts at secrecy, later that year the press interviewed several of the scientists.
Regarding Operation Alsos, Allied Intelligence described nuclear physicist Werner Heisenberg, the German nuclear energy project principal, as "worth more to us than ten divisions of Germans". In addition to rocketeers and nuclear physicists, the Allies also sought chemists, physicians, and naval weaponeers.
Meanwhile, the Technical Director of the German Army Rocket Center, Wernher von Braun, was jailed at P.O. Box 1142, a military-intelligence black site in Fort Hunt, Virginia, in the United States. Since the prison was unknown to the international community, its operation by the US was in violation of the Geneva Convention of 1929, which the United States had ratified. Although Von Braun's interrogators pressured him, he was not tortured; however in 1944 another PoW, U-boat Captain Werner Henke was shot and killed while climbing the fence at Fort Hunt.
Capture and detention.
The Allied zones of occupation in post-war Germany, highlighting the Soviet zone (red), the inner German border (heavy black line) and the zone from which British and American troops withdrew in July 1945 (purple). The provincial boundaries are those of Nazi Germany, before the present Länder (federal states) were established.
Early on, the United States created the Combined Intelligence Objectives Subcommittee (CIOS). This provided the information on targets for the T-Forces that went in and targeted scientific, military and industrial installations (and their employees) for their know-how. Initial priorities were advanced technology, such as infrared, that could be used in the war against Japan; finding out what technology had been passed on to Japan; and finally to halt the research. A project to halt the research was codenamed "Project Safehaven", and it was not initially targeted against the Soviet Union; rather the concern was that German scientists might emigrate and continue their research in countries such as Spain, Argentina or Egypt, all of which had sympathized with Nazi Germany. In order to avoid the complications involved with the emigration of German scientists, the CIOS was responsible for scouting and detaining high profile individuals for the deprivation of technological advancements in militant nations outside of the US.
Much U.S. effort was focused on Saxony and Thuringia, which by July 1, 1945 would become part of the Soviet Occupation zone. Many German research facilities and personnel had been evacuated to these states, particularly from the Berlin area. Fearing that the Soviet takeover would limit U.S. ability to exploit German scientific and technical expertise, and not wanting the Soviet Union to benefit from said expertise, the United States instigated an "evacuation operation" of scientific personnel from Saxony and Thuringia, issuing orders such as:
On orders of Military Government you are to report with your family and baggage as much as you can carry tomorrow noon at 1300 hours (Friday, 22 June 1945) at the town square in Bitterfeld. There is no need to bring winter clothing. Easily carried possessions, such as family documents, jewelry, and the like should be taken along. You will be transported by motor vehicle to the nearest railway station. From there you will travel on to the West. Please tell the bearer of this letter how large your family is.
By 1947 this evacuation operation had netted an estimated 1,800 technicians and scientists, along with 3,700 family members. Those with special skills or knowledge were taken to detention and interrogation centers, such as one code-named DUSTBIN, to be held and interrogated, in some cases for months.
A few of the scientists were gathered up in Operation Overcast, but most were transported to villages in the countryside where there were neither research facilities nor work; they were provided stipends and forced to report twice weekly to police headquarters to prevent them from leaving. The Joint Chiefs of Staff directive on research and teaching stated that technicians and scientists should be released "only after all interested agencies were satisfied that all desired intelligence information had been obtained from them".
On November 5, 1947, the Office of Military Government of the United States (OMGUS), which had jurisdiction over the western part of occupied Germany, held a conference to consider the status of the evacuees, the monetary claims that the evacuees had filed against the United States, and the "possible violation by the US of laws of war or Rules of Land Warfare". The OMGUS director of Intelligence R. L. Walsh initiated a program to resettle the evacuees in the Third World, which the Germans referred to as General Walsh's "Urwald-Programm" (jungle program), however this program never matured. In 1948, the evacuees received settlements of 69.5 million Reichsmarks from the U.S., a settlement that soon became severely devalued during the currency reform that introduced the Deutsche Mark as the official currency of western Germany.
John Gimbel concludes that the United States put some of Germany's best minds on ice for three years, therefore depriving the German recovery of their expertise.
Scientists.
German scientists repatriated from Sukhumi in February 1958. (see Forced labor of Germans in the Soviet Union)
In May 1945, the U.S. Navy "received in custody" Dr. Herbert A. Wagner, the inventor of the Hs 293 missile; for two years, he first worked at the Special Devices Center, at Castle Gould and at Hempstead House, Long Island, New York; in 1947, he moved to the Naval Air Station Point Mugu.
In August 1945, Colonel Holger Toftoy, head of the Rocket Branch of the Research and Development Division of the U.S. Army's Ordnance Corps, offered initial one-year contracts to the rocket scientists; 127 of them accepted. In September 1945, the first group of seven rocket scientists arrived at Fort Strong, located on Long Island in Boston harbor: Wernher von Braun, Erich W. Neubert, Theodor A. Poppel, August Schulze, Eberhard Rees, Wilhelm Jungert, and Walter Schwidetzky.
Beginning in late 1945, three rocket-scientist groups arrived in the United States for duty at Fort Bliss, Texas, and at White Sands Proving Grounds, New Mexico, as "War Department Special Employees".:27
In 1946, the United States Bureau of Mines employed seven German synthetic fuel scientists at a Fischer-Tropsch chemical plant in Louisiana, Missouri.
In early 1950, legal U.S. residency for some of the Project Paperclip specialists was effected through the U.S. consulate in Ciudad Juárez, Chihuahua, Mexico; thus, Nazi scientists legally entered the United States from Latin America.:226
Eighty-six aeronautical engineers were transferred to Wright Field, where the United States had Luftwaffe aircraft and equipment captured under Operation Lusty (Luftwaffe Secret Technology).
The United States Army Signal Corps employed 24 specialists ? including the physicists Georg Goubau, Gunter Guttwein, Georg Hass, Horst Kedesdy, and Kurt Lehovec; the physical chemists Rudolf Brill, Ernst Baars, and Eberhard Both; the geophysicist Helmut Weickmann; the optician Gerhard Schwesinger; and the engineers Eduard Gerber, Richard Guenther, and Hans Ziegler.
In 1959, 94 Operation Paperclip men went to the United States, including Friedwardt Winterberg and Friedrich Wigand. Throughout its operations to 1990, Operation Paperclip imported 1,600 men, as part of the intellectual reparations owed to the United States and the UK, some $10 billion in patents and industrial processes.
During the decades after they were included in Operation Paperclip, some scientists were investigated because of their activities during World War II. Arthur Rudolph was deported in 1984, but not prosecuted, and West Germany granted him citizenship. Similarly, Georg Rickhey, who came to the United States under Operation Paperclip in 1946, was returned to Germany to stand trial at the Dora Trial in 1947; he was acquitted, and returned to the United States in 1948, eventually becoming a U.S. citizen. The aeromedical library at Brooks Air Force Base in San Antonio, Texas, had been named after Hubertus Strughold in 1977. However, it was later renamed because documents from the Nuremberg War Crimes Tribunal linked Strughold to medical experiments in which inmates from Dachau were tortured and killed.
Key figures.
Rocketry
Rudi Beichel, Magnus von Braun, Wernher von Braun, Werner Dahm, Konrad Dannenberg, Kurt H. Debus, Walter Dornberger, Ernst R. G. Eckert, Krafft Arnold Ehricke, Otto Hirschler, Hermann H. Kurzweg, Fritz Mueller, Eberhard Rees, Gerhard Reisig, Georg Rickhey, Werner Rosinski, Ludwig Roth, Arthur Rudolph, Ernst Steinhoff, Ernst Stuhlinger, Bernhard Tessmann, and Georg von Tiesenhausen (see List of German rocket scientists in the US).
Aeronautics
Sighard F. Hoerner, Siegfried Knemeyer, Alexander Martin Lippisch, Hans Multhopp, Hans von Ohain, and Kurt Tank
Medicine ? biological weapons, chemical weapons, human experimentation, human factors in space medicine
Hans Antmann, Kurt Blome, Erich Traub, Walter Schreiber, and Hubertus Strughold.
Electronics
Hans Hollmann, Kurt Lehovec, Johannes Plendl, Heinz Schlicke and Hans K. Ziegler
Intelligence
Otto von Bolschwing and Reinhard Gehlen
Similar operations.
APPLEPIE: Project to capture and interrogate key Wehrmacht, RSHA AMT VI, and General Staff officers knowledgeable of the industry and economy of the USSR.
DUSTBIN (counterpart of ASHCAN): An Anglo-American military intelligence operation established first in Paris, then in Kransberg Castle, at Frankfurt.:314
ECLIPSE (1944): An unimplemented Air Disarmament Wing plan for post-war operations in Europe for destroying V-1 and V-2 missiles.:44
Safehaven: US project within ECLIPSE meant to prevent the escape of Nazi scientists from Allied-occupied Germany.
Field Information Agency; Technical (FIAT): US Army agency for securing the "major, and perhaps only, material reward of victory, namely, the advancement of science and the improvement of production and standards of living in the United Nations, by proper exploitation of German methods in these fields"; FIAT ended in 1947, when Operation Paperclip began functioning.:316
On April 26, 1946, the Joint Chiefs of Staff issued JCS Directive 1067/14 to General Eisenhower instructing that he "preserve from destruction and take under your control records, plans, books, documents, papers, files and scientific, industrial and other information and data belonging to . . . German organizations engaged in military research";:185 and that, excepting war-criminals, German scientists be detained for intelligence purposes as required.
National Interest/Project 63: Job placement assistance for Nazi engineers at Lockheed, Martin Marietta, North American Aviation, and other aeroplane companies, whilst American aerospace engineers were being laid off work.
Operation Alsos, Operation Big, Operation Epsilon, Russian Alsos: Soviet, American and British efforts to capture German nuclear secrets, equipment, and personnel.
Operation Backfire: A British effort at capturing rocket and aerospace technology from Cuxhaven.
Operation Lusty: US efforts to capture German aeronautical equipment, technology, and personnel.
Operation Osoaviakhim (sometimes transliterated as "Operation Ossavakim"), a Soviet counterpart of Operation Paperclip, involving German technicians, managers, skilled workers and their respective families who were relocated to the USSR in October 1946.
Operation Surgeon: British operation for denying German aeronautical expertise from the USSR, and for exploiting German scientists in furthering British research.
Special Mission V-2: April?May 1945 US operation, by Maj. William Bromley, that recovered parts and equipment for 100 V-2 missiles from a Mittelwerk underground factory in Kohnstein within the Soviet zone. Maj. James P. Hamill co-ordinated the transport of the equipment on 341 railroad cars with the 144th Motor Vehicle Assembly Company, from Nordhausen to Erfurt, just before the Soviets arrived. (see also Operation Blossom, Broomstick Scientists, Hermes project, Operations Sandy and Pushover)
Target Intelligence Committee: US project to exploit German cryptographers.
In popular culture.
In James Rollins' novel Ice Hunt (2003), the Russian commander Viktor Petkov cites multiple American research projects that violated modern standards of ethics and asks Matt Pike, "Then how do you justify Project Paperclip?", when Matt claims that US research, including the Tuskegee Experiment, was not comparable to the Nazis' experiments or to the human experimentation at the Grendel Ice Station in the book.(Chapter 16, page 16.)
In the 2014 film Captain America: The Winter Soldier, Operation Paperclip is attributed to the fictional agency S.H.I.E.L.D., recruiting German scientists after WWII including Dr. Arnim Zola. This ultimately backfires, as Zola recreates his former organization HYDRA from within, mixing S.H.I.E.L.D. employees with sleeper agents and sowing international chaos up until the modern day.
In The X-Files, in the third season's second episode (titled Paper Clip), Agent Mulder receives a tape with files containing stolen top secret information about experiments on extraterrestrials carried out in Operation Paperclip.
*
194."Paper Clip" The X-Files.
"Paper Clip" is the second episode of the third season of the American science fiction television series The X-Files. It premiered on the Fox network on September 29, 1995. It was directed by Rob Bowman, and written by series creator Chris Carter. "Paper Clip" featured guest appearances by Sheila Larken, Melinda McGraw and Nicholas Lea. The episode is one of those that explored the overarching mythology, or fictional history of The X-Files. "Paper Clip" earned a Nielsen household rating of 11.1, being watched by 17.2 million people in its initial broadcast. "Paper Clip" has received highly positive reviews from critics; it is generally considered by both critics and cast/crew as being among the best episodes of the series.
The show centers on FBI special agents Fox Mulder (David Duchovny) and Dana Scully (Gillian Anderson), who work on cases linked to the paranormal, called X-Files. In this episode, Mulder and Scully investigate information gleaned from secret government records, finding that a Nazi scientist working as part of Operation Paperclip may have been responsible for creating a race of human-alien hybrids. "Paper Clip" concludes a three-episode storyline, carrying on from the second season finale "Anasazi" and the third season premiere "The Blessing Way".
The creators of the series likened themes of the episode to the Star Wars trilogy, referring to the revelations about Mulder's father, and Sophie's Choice, referring to how the Mulders were forced to choose Fox or Samantha to be taken. In addition, the episode has been critically examined, due to its themes pertaining to "arrogated" scientists and their "connection to ancient evil".
Plot.
Continuing from the previous episode, Dana Scully (Gillian Anderson) and Walter Skinner (Mitch Pileggi) hold each other at gunpoint. Fox Mulder (David Duchovny), the person lingering outside his apartment, bursts in and forces Skinner to put his gun down. He also demands that Skinner surrender the digital tape. Skinner insists on keeping the tape, saying it is their only leverage in exposing the conspiracy.
The agents visit The Lone Gunmen, showing them an old photo featuring Bill Mulder, The Smoking Man, Deep Throat, and other members of the Syndicate. The Lone Gunmen also recognize Victor Klemper, a notorious Nazi scientist who was brought to the United States under Operation Paperclip. Melvin Frohike informs Scully of her sister Melissa's condition. Mulder persuades Scully not to visit Melissa at the hospital, since she could be targeted there.
Furious that the wrong person was murdered, the Syndicate demands that the Smoking Man produce the tape. The Smoking Man promises to do so the following day. Meanwhile, Mulder and Scully visit Klemper, who says that the photo was taken at a former mining facility in West Virginia. After the agents leave, Klemper calls the Well-Manicured Man and informs him that Mulder is alive. The news causes the Syndicate to further mistrust the Smoking Man. Meanwhile, at the hospital, Albert Hosteen visits Melissa while a suited man loiters nearby.
Mulder and Scully arrive at the mining facility and, using the code for Napier's constant given to them by Klemper, unlock one of the reinforced doors inside. The agents discover a large complex of filing cabinets containing smallpox vaccination records and tissue samples. Mulder finds his sister's file and finds that it was originally meant for him. Meanwhile, Skinner tells the Smoking Man that he may have found the digital tape. The Smoking Man is agitated at this, insisting that he will not make a deal with Skinner and tacitly threatening his life.
Hearing noise, Mulder heads outside and witnesses a UFO flying overhead; inside, small beings run past Scully. Cars full of armed soldiers arrive, forcing the agents to flee. The agents meet with Skinner at a diner in rural Maryland. Skinner wants to turn over the tape in exchange for their reinstatement and safety. After initially objecting, Mulder agrees to let Skinner turn the tape over. Skinner heads to see Melissa in the hospital and is told by Albert of the mysterious blue-suited man outside. Skinner chases the man to a stairwell where he is attacked by Alex Krycek and Luis Cardinal, who beat him unconscious and steal the tape.
Krycek narrowly escapes an attempt on his life when his car explodes. He subsequently phones the Smoking Man, telling him that he has the tape and will make its contents public should anyone come after him. The Smoking Man lies to the rest of the Syndicate, telling them that Scully's would-be assassin was killed in the car bombing and that the tape has been destroyed with him. Mulder and Scully return to Klemper's greenhouse, finding the Well Manicured Man there. He admits to knowing Mulder's father and states that he helped gather genetic data for post-apocalyptic identification, data Klemper used to work on alien-human hybrids. Samantha was taken to ensure Bill Mulder's silence after he learned of the experiments.
Mulder confronts his mother, who tells him that his father chose that Samantha be taken. At FBI headquarters, Skinner once again meets with the Smoking Man about the tape. The Smoking Man calls Skinner's bluff, knowing he no longer has the tape, but Skinner reveals that Albert and twenty other Navajo have memorized the contents of the tape and are ready to reveal it if either Mulder or Scully are harmed. Mulder meets with Scully at the hospital, who reveals that her sister died a few hours before. Mulder tells Scully that he believes that the truth is still in the X-Files. Scully tells him that she's heard the truth, and now what she wants are the answers.
Themes.
Jan Delasara, in the book '"PopLit, PopCult and The X-Files" argues that episodes like "Paper Clip", or the later episodes like "Nisei" and "731", show the public's trust in science "eroding", Delasara proposes that "arrogated" scientists who are "rework[ing] the fabric of life" are causing the public's faith in science to fade drastically, "a concern", she notes, "that is directly addressed by X-Files episodes".
Moreover, she notes that almost all of the scientists portrayed in The X-Files are depicted with a "connection to ancient evil", with the lone exception being Agent Scully. In "Paper Clip" one of the main scientists is an ex-Nazi. As the episode proceeds, his scientific pursuits soon begin to paint him as the archetypical scientist who "goes too far", a serious factor Delasara argues "'alienates' [the public] further from science and its practitioners".
*
Geen opmerkingen:
Een reactie posten